Drug interactions
Nafcillin + Ranolazine
Severity: Major
Nafcillin and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and can lower the concentrations of CYP3A substrates, which may reduce ranolazine efficacy. The effect is likely less than with rifampin but can be clinically important.
What this interaction means in plain words
Nafcillin and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction increases ranolazine metabolism.
What to do
Monitor anginal symptoms and consider an alternative antibiotic. Avoid prolonged coadministration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Nafcillin with Ranolazine?
MediHelp rates the interaction as major. Nafcillin and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nafcillin induces CYP3A4 and can lower the concentrations of CYP3A substrates, which may reduce ranolazine efficacy. The effect is likely less than with rifampin but can be clinically important.
How serious is the interaction between Nafcillin and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anginal symptoms and consider an alternative antibiotic. Avoid prolonged coadministration.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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