Drug interactions
Nafcillin + Tramadol
Severity: Moderate
Nafcillin and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower tramadol concentrations, potentially reducing analgesia. Withdrawal of nafcillin may later lead to rising tramadol levels.
What this interaction means in plain words
Nafcillin and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increasing tramadol clearance.
What to do
Monitor pain control during nafcillin therapy and adjust tramadol or switch analgesic if needed. Watch for tramadol adverse effects after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Nafcillin with Tramadol?
MediHelp rates the interaction as moderate. Nafcillin and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may lower tramadol concentrations, potentially reducing analgesia. Withdrawal of nafcillin may later lead to rising tramadol levels.
How serious is the interaction between Nafcillin and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control during nafcillin therapy and adjust tramadol or switch analgesic if needed. Watch for tramadol adverse effects after nafcillin is stopped.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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