Drug interactions
Nafcillin + Trazodone
Severity: Minor
Nafcillin and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4, which could reduce trazodone levels and weaken its effect. The interaction is mainly established for other CYP3A4 substrates, and the effect on trazodone is predicted rather than documented.
What this interaction means in plain words
Nafcillin and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin-mediated induction of CYP3A4 may increase trazodone metabolism.
What to do
Monitor for loss of antidepressant or hypnotic effect during nafcillin courses and adjust the trazodone dose if needed. Reassess after nafcillin is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Nafcillin with Trazodone?
MediHelp rates the interaction as minor. Nafcillin and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4, which could reduce trazodone levels and weaken its effect. The interaction is mainly established for other CYP3A4 substrates, and the effect on trazodone is predicted rather than documented.
How serious is the interaction between Nafcillin and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant or hypnotic effect during nafcillin courses and adjust the trazodone dose if needed. Reassess after nafcillin is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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