Drug interactions
Nafcillin + Vortioxetine
Severity: Moderate
Nafcillin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and may lower vortioxetine concentrations during prolonged treatment. The effect is likely modest and limited to the duration of therapy.
What this interaction means in plain words
Nafcillin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces hepatic CYP3A4 and related enzymes, increasing vortioxetine clearance.
What to do
Monitor for reduced antidepressant effect during extended nafcillin courses and consider increasing the vortioxetine dose if needed. Return to the original dose after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Nafcillin with Vortioxetine?
MediHelp rates the interaction as moderate. Nafcillin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is an inducer of CYP3A4 and may lower vortioxetine concentrations during prolonged treatment. The effect is likely modest and limited to the duration of therapy.
How serious is the interaction between Nafcillin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant effect during extended nafcillin courses and consider increasing the vortioxetine dose if needed. Return to the original dose after nafcillin is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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