Drug interactions
Nafcillin + Zonisamide
Severity: Minor
Nafcillin and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower zonisamide concentrations, since zonisamide is partly cleared by CYP3A4. Reduced exposure could weaken seizure control, although clinical reports are sparse.
What this interaction means in plain words
Nafcillin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by nafcillin increases the metabolic clearance of zonisamide.
What to do
Monitor seizure control during and after a nafcillin course in patients with epilepsy. Consider checking zonisamide response or levels if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Nafcillin with Zonisamide?
MediHelp rates the interaction as minor. Nafcillin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer and may lower zonisamide concentrations, since zonisamide is partly cleared by CYP3A4. Reduced exposure could weaken seizure control, although clinical reports are sparse.
How serious is the interaction between Nafcillin and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control during and after a nafcillin course in patients with epilepsy. Consider checking zonisamide response or levels if breakthrough seizures occur.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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