Drug interactions
Nalbuphine + Procarbazine
Severity: Moderate
Nalbuphine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and opioids given with MAO inhibitors may produce excessive sedation, respiratory depression and hypotension. The effect is mainly additive CNS and hemodynamic depression in this pairing.
What this interaction means in plain words
Nalbuphine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine may potentiate opioid CNS depressant and hypotensive effects; the mechanism is not fully established.
What to do
Use a reduced initial nalbuphine dose with careful titration, and monitor sedation, respiratory rate and blood pressure. Consider an alternative analgesic if the patient is already sedated or hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Nalbuphine with Procarbazine?
MediHelp rates the interaction as moderate. Nalbuphine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting activity, and opioids given with MAO inhibitors may produce excessive sedation, respiratory depression and hypotension. The effect is mainly additive CNS and hemodynamic depression in this pairing.
How serious is the interaction between Nalbuphine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced initial nalbuphine dose with careful titration, and monitor sedation, respiratory rate and blood pressure. Consider an alternative analgesic if the patient is already sedated or hypotensive.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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