Drug interactions
Nalbuphine + Quetiapine
Severity: Moderate
Nalbuphine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is sedating and can cause orthostatic hypotension, and together with an opioid these effects are increased. Patients may be drowsy, dizzy and at higher risk of falls.
What this interaction means in plain words
Nalbuphine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and hypotensive effects via histamine H1 and alpha-1 blockade.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Advise slow position changes and avoidance of driving until the response is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Nalbuphine with Quetiapine?
MediHelp rates the interaction as moderate. Nalbuphine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is sedating and can cause orthostatic hypotension, and together with an opioid these effects are increased. Patients may be drowsy, dizzy and at higher risk of falls.
How serious is the interaction between Nalbuphine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Advise slow position changes and avoidance of driving until the response is established.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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