Drug interactions
Nalbuphine + Thioridazine
Severity: Major
Nalbuphine and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is strongly sedating and hypotensive, so combining it with an opioid increases drowsiness, hypotension and respiratory depression. Thioridazine also has notable QT-prolonging effects, which require separate attention.
What this interaction means in plain words
Nalbuphine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nalbuphine belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and hypotensive effects.
What to do
Use only if needed, with reduced doses, and monitor sedation, blood pressure and respiration. Continue ECG and electrolyte monitoring for thioridazine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Nalbuphine with Thioridazine?
MediHelp rates the interaction as major. Nalbuphine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine is strongly sedating and hypotensive, so combining it with an opioid increases drowsiness, hypotension and respiratory depression. Thioridazine also has notable QT-prolonging effects, which require separate attention.
How serious is the interaction between Nalbuphine and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if needed, with reduced doses, and monitor sedation, blood pressure and respiration. Continue ECG and electrolyte monitoring for thioridazine.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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