Drug interactions
Nalbuphine + Ziprasidone
Severity: Moderate
Nalbuphine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and combined use may increase sedation and dizziness. Ziprasidone also prolongs the QT interval, though nalbuphine is not known to add meaningfully to this.
What this interaction means in plain words
Nalbuphine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excess sedation and orthostatic symptoms, and reduce doses if needed. Keep up routine ECG and electrolyte monitoring for ziprasidone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Nalbuphine with Ziprasidone?
MediHelp rates the interaction as moderate. Nalbuphine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and combined use may increase sedation and dizziness. Ziprasidone also prolongs the QT interval, though nalbuphine is not known to add meaningfully to this.
How serious is the interaction between Nalbuphine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and orthostatic symptoms, and reduce doses if needed. Keep up routine ECG and electrolyte monitoring for ziprasidone.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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