Drug interactions
Naldemedine + Propafenone
Severity: Minor
Naldemedine and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-glycoprotein, and naldemedine is a P-gp substrate, so naldemedine exposure may rise. This could increase opioid-withdrawal-type gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibits P-glycoprotein efflux, reducing naldemedine efflux and increasing its absorption and exposure.
What to do
Monitor for abdominal pain, diarrhea and other naldemedine adverse effects. No routine dose change is needed unless symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Propafenone?
MediHelp rates the interaction as minor. Naldemedine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone inhibits P-glycoprotein, and naldemedine is a P-gp substrate, so naldemedine exposure may rise. This could increase opioid-withdrawal-type gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and other naldemedine adverse effects. No routine dose change is needed unless symptoms develop.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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