Drug interactions
Naldemedine + Secobarbital
Severity: Moderate
Naldemedine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower naldemedine concentrations through CYP3A4 induction. Naldemedine labeling advises avoiding strong CYP3A inducers because reduced exposure may decrease its effect against opioid-induced constipation.
What this interaction means in plain words
Naldemedine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases the metabolic clearance of naldemedine.
What to do
Avoid the combination where possible and use a non-inducing hypnotic. Monitor bowel function and consider an alternative laxative if the response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Secobarbital?
MediHelp rates the interaction as moderate. Naldemedine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower naldemedine concentrations through CYP3A4 induction. Naldemedine labeling advises avoiding strong CYP3A inducers because reduced exposure may decrease its effect against opioid-induced constipation.
How serious is the interaction between Naldemedine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-inducing hypnotic. Monitor bowel function and consider an alternative laxative if the response is lost.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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