Drug interactions
Naldemedine + Sertraline
Severity: Minor
Naldemedine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is metabolised mainly by CYP3A4, and sertraline is only a weak CYP3A4 inhibitor. Any increase in naldemedine exposure is likely small, with gastrointestinal adverse effects as the main concern.
What this interaction means in plain words
Naldemedine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by sertraline may slightly reduce naldemedine metabolism.
What to do
No dose adjustment is needed. Watch for abdominal pain or diarrhea and reassess if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Sertraline?
MediHelp rates the interaction as minor. Naldemedine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is metabolised mainly by CYP3A4, and sertraline is only a weak CYP3A4 inhibitor. Any increase in naldemedine exposure is likely small, with gastrointestinal adverse effects as the main concern.
How serious is the interaction between Naldemedine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Watch for abdominal pain or diarrhea and reassess if these occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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