Drug interactions
Naloxegol + Nicardipine
Severity: Moderate
Naloxegol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-glycoprotein substrate, and higher exposure can cause opioid withdrawal symptoms and gastrointestinal effects. Nicardipine is a weaker CYP3A4 inhibitor than the strong inhibitors that are contraindicated, so a moderate-inhibitor level of effect is more likely.
What this interaction means in plain words
Naloxegol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naloxegol belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine inhibition of CYP3A4 metabolism of naloxegol, increasing its systemic exposure.
What to do
Reduce naloxegol to the lower labeled dose and monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Stop naloxegol if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Nicardipine?
MediHelp rates the interaction as moderate. Naloxegol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 and P-glycoprotein substrate, and higher exposure can cause opioid withdrawal symptoms and gastrointestinal effects. Nicardipine is a weaker CYP3A4 inhibitor than the strong inhibitors that are contraindicated, so a moderate-inhibitor level of effect is more likely.
How serious is the interaction between Naloxegol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce naloxegol to the lower labeled dose and monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Stop naloxegol if these occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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