Drug interactions
Naloxegol + Sertraline
Severity: Minor
Naloxegol and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-glycoprotein substrate, and inhibitors raise its exposure, which can precipitate opioid withdrawal symptoms and gastrointestinal effects. Sertraline is a weak CYP3A4 inhibitor, so the effect is expected to be small.
What this interaction means in plain words
Naloxegol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naloxegol belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reducing naloxegol clearance.
What to do
No routine adjustment is needed; monitor for abdominal pain, diarrhoea or withdrawal symptoms. Reduce naloxegol to 12.5 mg daily if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naloxegol and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Sertraline?
MediHelp rates the interaction as minor. Naloxegol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naloxegol is a CYP3A4 and P-glycoprotein substrate, and inhibitors raise its exposure, which can precipitate opioid withdrawal symptoms and gastrointestinal effects. Sertraline is a weak CYP3A4 inhibitor, so the effect is expected to be small.
How serious is the interaction between Naloxegol and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for abdominal pain, diarrhoea or withdrawal symptoms. Reduce naloxegol to 12.5 mg daily if they occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
