Drug interactions
Naloxegol + Ticagrelor
Severity: Minor
Naloxegol and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-gp substrate, and ticagrelor is a weak CYP3A and P-gp inhibitor. Naloxegol levels may rise modestly, increasing gastrointestinal adverse effects or opioid withdrawal symptoms.
What this interaction means in plain words
Naloxegol and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naloxegol belongs to Gastrointestinal Tract; Ticagrelor belongs to Cardiovascular.
Why it happens
Ticagrelor weakly inhibits CYP3A4 and P-gp, reducing naloxegol clearance.
What to do
Monitor for abdominal pain, diarrhea or opioid withdrawal symptoms. Reduce naloxegol dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Ticagrelor?
MediHelp rates the interaction as minor. Naloxegol and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naloxegol is a CYP3A4 and P-gp substrate, and ticagrelor is a weak CYP3A and P-gp inhibitor. Naloxegol levels may rise modestly, increasing gastrointestinal adverse effects or opioid withdrawal symptoms.
How serious is the interaction between Naloxegol and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea or opioid withdrawal symptoms. Reduce naloxegol dose if adverse effects occur.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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