Drug interactions
Naloxegol + Verapamil
Severity: Moderate
Naloxegol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise naloxegol exposure, increasing the likelihood of abdominal pain, diarrhea and opioid withdrawal symptoms.
What this interaction means in plain words
Naloxegol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naloxegol belongs to Gastrointestinal Tract; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and P-gp, which clear naloxegol.
What to do
Reduce naloxegol to 12.5 mg daily if the combination is needed, and monitor for gastrointestinal and withdrawal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Verapamil?
MediHelp rates the interaction as moderate. Naloxegol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise naloxegol exposure, increasing the likelihood of abdominal pain, diarrhea and opioid withdrawal symptoms.
How serious is the interaction between Naloxegol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce naloxegol to 12.5 mg daily if the combination is needed, and monitor for gastrointestinal and withdrawal symptoms.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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