Drug interactions
Naproxen + Succinylcholine
Severity: Minor
Naproxen and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine raises serum potassium transiently, while NSAIDs rarely cause hyperkalemia, mainly in patients with renal impairment. There is no well-established clinically meaningful interaction at usual doses.
What this interaction means in plain words
Naproxen and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naproxen belongs to Musculoskeletal; Succinylcholine belongs to Musculoskeletal.
Why it happens
Theoretical additive potassium elevation; no established mechanism of significant interaction.
What to do
No routine action is needed. Check potassium in patients with renal impairment or other hyperkalemia risks before anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Naproxen with Succinylcholine?
MediHelp rates the interaction as minor. Naproxen and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine raises serum potassium transiently, while NSAIDs rarely cause hyperkalemia, mainly in patients with renal impairment. There is no well-established clinically meaningful interaction at usual doses.
How serious is the interaction between Naproxen and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check potassium in patients with renal impairment or other hyperkalemia risks before anesthesia.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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