Drug interactions
Naproxen + Torsemide
Severity: Moderate
Naproxen and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics by causing sodium and water retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Naproxen and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and natriuretic response to loop diuretics.
What to do
Monitor weight, blood pressure, edema and serum creatinine when naproxen is used with torsemide. Avoid prolonged NSAID use in heart failure and renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Torsemide
Frequently asked questions
Can I take Naproxen with Torsemide?
MediHelp rates the interaction as moderate. Naproxen and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics by causing sodium and water retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Naproxen and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure, edema and serum creatinine when naproxen is used with torsemide. Avoid prolonged NSAID use in heart failure and renal impairment.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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