Drug interactions
Naproxen + Vitamin k1
Severity: Minor
Naproxen and Vitamin k1: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phytonadione promotes clotting factor synthesis, while naproxen inhibits platelet function. They do not meaningfully interact in a patient not on anticoagulants, and the combined effect on bleeding is not clinically relevant.
What this interaction means in plain words
Naproxen and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naproxen belongs to Musculoskeletal; Vitamin k1 belongs to Cardiovascular.
Why it happens
No clinically significant interaction mechanism; effects act on different parts of hemostasis.
What to do
No action needed. In patients on warfarin, note that naproxen still increases bleeding risk regardless of vitamin K.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Cholestyramine + Vitamin k1 Moderate
- Colestipol + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Orlistat + Vitamin k1 Moderate
Frequently asked questions
Can I take Naproxen with Vitamin k1?
MediHelp rates the interaction as minor. Naproxen and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phytonadione promotes clotting factor synthesis, while naproxen inhibits platelet function. They do not meaningfully interact in a patient not on anticoagulants, and the combined effect on bleeding is not clinically relevant.
How serious is the interaction between Naproxen and Vitamin k1?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed. In patients on warfarin, note that naproxen still increases bleeding risk regardless of vitamin K.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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