Drug interactions
Naratriptan + Procarbazine
Severity: Moderate
Naratriptan and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitor activity and, with a triptan, may raise the risk of serotonin syndrome or hypertensive reactions. Naratriptan is not metabolized mainly by MAO-A, so the risk is mostly theoretical.
What this interaction means in plain words
Naratriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Procarbazine's MAO inhibition combined with serotonergic triptan activity may increase serotonergic toxicity.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and blood pressure changes after the combination is started. Use a non-serotonergic migraine treatment if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naratriptan and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Naratriptan with Procarbazine?
MediHelp rates the interaction as moderate. Naratriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitor activity and, with a triptan, may raise the risk of serotonin syndrome or hypertensive reactions. Naratriptan is not metabolized mainly by MAO-A, so the risk is mostly theoretical.
How serious is the interaction between Naratriptan and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and blood pressure changes after the combination is started. Use a non-serotonergic migraine treatment if possible.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
