Drug interactions
Nateglinide + Piroxicam
Severity: Minor
Nateglinide and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP2C9 substrates, so competition could slightly raise exposure to either. Clinically important effects are unlikely, though hypoglycemia is theoretically possible.
What this interaction means in plain words
Nateglinide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Competition for CYP2C9 metabolism between the two substrates.
What to do
No dose change is routinely required. Advise patients to monitor blood glucose and report symptoms of hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Piroxicam?
MediHelp rates the interaction as minor. Nateglinide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are CYP2C9 substrates, so competition could slightly raise exposure to either. Clinically important effects are unlikely, though hypoglycemia is theoretically possible.
How serious is the interaction between Nateglinide and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Advise patients to monitor blood glucose and report symptoms of hypoglycemia.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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