Drug interactions
Nebivolol + Nicardipine
Severity: Moderate
Nebivolol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure and are often used together, but combined use can cause excessive hypotension. Dihydropyridines may cause reflex tachycardia that the beta-blocker blunts, and negative inotropy is a small concern in heart failure.
What this interaction means in plain words
Nebivolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of beta-blockade and calcium channel blockade.
What to do
Monitor blood pressure and heart rate, especially when starting or increasing doses. Use caution in patients with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nebivolol with Nicardipine?
MediHelp rates the interaction as moderate. Nebivolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure and are often used together, but combined use can cause excessive hypotension. Dihydropyridines may cause reflex tachycardia that the beta-blocker blunts, and negative inotropy is a small concern in heart failure.
How serious is the interaction between Nebivolol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially when starting or increasing doses. Use caution in patients with left ventricular dysfunction.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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