Drug interactions
Nebivolol + Phentolamine
Severity: Moderate
Nebivolol and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is a non-selective alpha-blocker that causes vasodilation and can produce marked hypotension and reflex tachycardia. Nebivolol adds blood pressure lowering and blunts the compensatory tachycardia, so hypotension may be more pronounced.
What this interaction means in plain words
Nebivolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade combined with beta-blockade and nebivolol-related vasodilation.
What to do
Monitor blood pressure and heart rate when combining, particularly during parenteral phentolamine use. Adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Nebivolol with Phentolamine?
MediHelp rates the interaction as moderate. Nebivolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is a non-selective alpha-blocker that causes vasodilation and can produce marked hypotension and reflex tachycardia. Nebivolol adds blood pressure lowering and blunts the compensatory tachycardia, so hypotension may be more pronounced.
How serious is the interaction between Nebivolol and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining, particularly during parenteral phentolamine use. Adjust doses if symptomatic hypotension develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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