Drug interactions
Nebivolol + Pilocarpine
Severity: Moderate
Nebivolol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist that can cause bradycardia and conduction disturbances when absorbed systemically. Combined with nebivolol, these effects may be additive, mainly with oral pilocarpine.
What this interaction means in plain words
Nebivolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive cardiac slowing from muscarinic stimulation and beta-1 blockade.
What to do
Monitor heart rate and conduction in patients on oral pilocarpine with nebivolol, particularly those with cardiac disease. Ophthalmic use seldom needs any action.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Nebivolol with Pilocarpine?
MediHelp rates the interaction as moderate. Nebivolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist that can cause bradycardia and conduction disturbances when absorbed systemically. Combined with nebivolol, these effects may be additive, mainly with oral pilocarpine.
How serious is the interaction between Nebivolol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and conduction in patients on oral pilocarpine with nebivolol, particularly those with cardiac disease. Ophthalmic use seldom needs any action.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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