Drug interactions
Nebivolol + Sertraline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Sertraline (a moderate CYP2D6 inhibitor) can increase nebivolol exposure, raising risk of bradycardia, hypotension, and dizziness.
Mechanism of action
Pharmacokinetic via CYP2D6 inhibition (nebivolol is CYP2D6 substrate); additive pharmacodynamic BP/HR lowering.
Clinical management
Use lower initial nebivolol doses or titrate cautiously; monitor heart rate and blood pressure; assess for bradycardia, fatigue, or syncope; consider ECG if symptomatic.
Drug reference
References
- Bystolic (nebivolol) Prescribing Information — FDA Label
- Nebivolol: Drug Interactions – CYP2D6 inhibitors — Lexicomp
Frequently asked questions
Can I take Nebivolol with Sertraline?
The interaction is rated: Moderate. Sertraline (a moderate CYP2D6 inhibitor) can increase nebivolol exposure, raising risk of bradycardia, hypotension, and dizziness.
How serious is the interaction between Nebivolol and Sertraline?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Nebivolol and Sertraline managed?
Use lower initial nebivolol doses or titrate cautiously; monitor heart rate and blood pressure; assess for bradycardia, fatigue, or syncope; consider ECG if symptomatic.
Why do Nebivolol and Sertraline interact?
Pharmacokinetic via CYP2D6 inhibition (nebivolol is CYP2D6 substrate); additive pharmacodynamic BP/HR lowering.
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