Drug interactions
Nebivolol + Terbinafine
Severity: Moderate
Nebivolol and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is cleared mainly by CYP2D6, so terbinafine can raise levels of the parent drug. This may lead to bradycardia, hypotension and fatigue.
What this interaction means in plain words
Nebivolol and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6-mediated metabolism of nebivolol.
What to do
Monitor heart rate and blood pressure during co-therapy. Reduce the nebivolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Terbinafine?
MediHelp rates the interaction as moderate. Nebivolol and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is cleared mainly by CYP2D6, so terbinafine can raise levels of the parent drug. This may lead to bradycardia, hypotension and fatigue.
How serious is the interaction between Nebivolol and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during co-therapy. Reduce the nebivolol dose if bradycardia or hypotension occurs.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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