Drug interactions
Nebivolol + Thioridazine
Severity: Major
Nebivolol and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine inhibits CYP2D6, the main enzyme metabolizing nebivolol, so nebivolol exposure may rise with more bradycardia and hypotension. Thioridazine itself prolongs the QT interval and has additive hypotensive effects, which increases concern.
What this interaction means in plain words
Nebivolol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nebivolol belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by thioridazine reduces nebivolol clearance, plus additive hypotensive and cardiac conduction effects.
What to do
Avoid the combination if possible, or use a lower nebivolol dose with close monitoring of heart rate, blood pressure and ECG including QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Nebivolol with Thioridazine?
MediHelp rates the interaction as major. Nebivolol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine inhibits CYP2D6, the main enzyme metabolizing nebivolol, so nebivolol exposure may rise with more bradycardia and hypotension. Thioridazine itself prolongs the QT interval and has additive hypotensive effects, which increases concern.
How serious is the interaction between Nebivolol and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use a lower nebivolol dose with close monitoring of heart rate, blood pressure and ECG including QTc.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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