Drug interactions
Nebivolol + Tolfenamic acid
Severity: Moderate
Nebivolol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers through sodium and water retention and reduced vasodilatory prostaglandins. Blood pressure control may worsen with prolonged use.
What this interaction means in plain words
Nebivolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes fluid retention and vasoconstriction, antagonizing the antihypertensive effect.
What to do
Monitor blood pressure when NSAIDs are used regularly and use the lowest effective NSAID dose for the shortest time. Consider paracetamol or another alternative if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Nebivolol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Nebivolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers through sodium and water retention and reduced vasodilatory prostaglandins. Blood pressure control may worsen with prolonged use.
How serious is the interaction between Nebivolol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAIDs are used regularly and use the lowest effective NSAID dose for the shortest time. Consider paracetamol or another alternative if control is lost.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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