Drug interactions
Nefazodone + Pregabalin
Severity: Moderate
Nefazodone and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a sedating antidepressant and pregabalin also causes drowsiness and dizziness, so the combination may increase sedation and impair alertness. Serious respiratory depression is unlikely unless other depressants are also involved.
What this interaction means in plain words
Nefazodone and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and monitor for sedation and dizziness, particularly at initiation and after dose increases. Warn the patient about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Nefazodone with Pregabalin?
MediHelp rates the interaction as moderate. Nefazodone and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a sedating antidepressant and pregabalin also causes drowsiness and dizziness, so the combination may increase sedation and impair alertness. Serious respiratory depression is unlikely unless other depressants are also involved.
How serious is the interaction between Nefazodone and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and dizziness, particularly at initiation and after dose increases. Warn the patient about driving and operating machinery.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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