Drug interactions
Nefazodone + Ranolazine
Severity: Contraindicated
Nefazodone and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can substantially raise ranolazine levels. This increases the risk of QT prolongation and dose-related adverse effects.
What this interaction means in plain words
Nefazodone and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 metabolism of ranolazine by nefazodone.
What to do
Avoid the combination in line with ranolazine labeling on strong CYP3A inhibitors. Choose a different antidepressant or antianginal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Nefazodone with Ranolazine?
MediHelp rates the interaction as contraindicated. Nefazodone and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a strong CYP3A4 inhibitor and can substantially raise ranolazine levels. This increases the risk of QT prolongation and dose-related adverse effects.
How serious is the interaction between Nefazodone and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with ranolazine labeling on strong CYP3A inhibitors. Choose a different antidepressant or antianginal.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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