Drug interactions
Nefazodone + Rizatriptan
Severity: Moderate
Nefazodone and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity, so adding a triptan may rarely precipitate serotonin syndrome. The risk is generally low but the consequences can be serious.
What this interaction means in plain words
Nefazodone and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism and nefazodone serotonin reuptake inhibition with 5-HT2A antagonism.
What to do
Monitor for agitation, tremor, sweating, hyperthermia and clonus after starting or adjusting doses. Discontinue the serotonergic agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Nefazodone with Rizatriptan?
MediHelp rates the interaction as moderate. Nefazodone and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity, so adding a triptan may rarely precipitate serotonin syndrome. The risk is generally low but the consequences can be serious.
How serious is the interaction between Nefazodone and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, sweating, hyperthermia and clonus after starting or adjusting doses. Discontinue the serotonergic agents if serotonin syndrome is suspected.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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