Drug interactions
Nefazodone + Ruxolitinib
Severity: Major
Nefazodone and Ruxolitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can raise ruxolitinib exposure considerably. Higher exposure increases the risk of dose-related myelosuppression, especially thrombocytopenia, and infection.
What this interaction means in plain words
Nefazodone and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ruxolitinib reduces its clearance.
What to do
Reduce the ruxolitinib dose according to labeling for strong CYP3A4 inhibitors, or choose an alternative antidepressant. Monitor complete blood counts, particularly platelets, more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Nefazodone with Ruxolitinib?
MediHelp rates the interaction as major. Nefazodone and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can raise ruxolitinib exposure considerably. Higher exposure increases the risk of dose-related myelosuppression, especially thrombocytopenia, and infection.
How serious is the interaction between Nefazodone and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose according to labeling for strong CYP3A4 inhibitors, or choose an alternative antidepressant. Monitor complete blood counts, particularly platelets, more frequently.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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