Drug interactions
Nefazodone + Tedizolid
Severity: Moderate
Nefazodone and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity and tedizolid weakly inhibits MAO. Serotonin syndrome is possible, although clinical studies of tedizolid showed little serotonergic effect.
What this interaction means in plain words
Nefazodone and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive serotonergic effect from weak MAO inhibition and serotonin reuptake inhibition.
What to do
Monitor for signs of serotonin toxicity during co-therapy. Use an alternative antibiotic if the patient has other serotonergic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Nefazodone with Tedizolid?
MediHelp rates the interaction as moderate. Nefazodone and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity and tedizolid weakly inhibits MAO. Serotonin syndrome is possible, although clinical studies of tedizolid showed little serotonergic effect.
How serious is the interaction between Nefazodone and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity during co-therapy. Use an alternative antibiotic if the patient has other serotonergic risk factors.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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