Drug interactions
Nelfinavir + Pravastatin
Severity: Moderate
Nelfinavir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may modestly alter pravastatin exposure and could increase myopathy risk. Pravastatin is a usual statin choice with protease inhibitors.
What this interaction means in plain words
Nelfinavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Pravastatin belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition by nelfinavir reducing hepatic uptake of pravastatin.
What to do
Use the lowest effective pravastatin dose and monitor for muscle symptoms; check CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Pravastatin?
MediHelp rates the interaction as moderate. Nelfinavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may modestly alter pravastatin exposure and could increase myopathy risk. Pravastatin is a usual statin choice with protease inhibitors.
How serious is the interaction between Nelfinavir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pravastatin dose and monitor for muscle symptoms; check CK if they occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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