Drug interactions
Nelfinavir + Voriconazole
Severity: Moderate
Nelfinavir and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole and nelfinavir may each raise the other's exposure, since both are metabolized by and inhibit CYP enzymes. This can increase dose-related adverse effects of either drug, including hepatic effects, visual disturbances and gastrointestinal toxicity.
What this interaction means in plain words
Nelfinavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 (and CYP2C19) which metabolize nelfinavir, while nelfinavir may in turn inhibit voriconazole clearance via CYP3A4 and CYP2C19.
What to do
Monitor liver function tests and for voriconazole and nelfinavir adverse effects, and consider voriconazole trough concentrations. Adjust doses based on tolerability and levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nelfinavir and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Voriconazole?
MediHelp rates the interaction as moderate. Nelfinavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole and nelfinavir may each raise the other's exposure, since both are metabolized by and inhibit CYP enzymes. This can increase dose-related adverse effects of either drug, including hepatic effects, visual disturbances and gastrointestinal toxicity.
How serious is the interaction between Nelfinavir and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for voriconazole and nelfinavir adverse effects, and consider voriconazole trough concentrations. Adjust doses based on tolerability and levels.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
