Drug interactions
Neomycin + Vancomycin
Severity: Moderate
Neomycin and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have nephrotoxic and ototoxic potential, and intravenous vancomycin with an aminoglycoside raises acute kidney injury risk. Oral neomycin is minimally absorbed, but absorption can increase with impaired renal function or damaged gut mucosa.
What this interaction means in plain words
Neomycin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity, with greater systemic neomycin exposure when absorption or renal clearance is altered.
What to do
Monitor serum creatinine and vancomycin trough or AUC-based levels during combined therapy. Check hearing if therapy is prolonged or renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Neomycin with Vancomycin?
MediHelp rates the interaction as moderate. Neomycin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have nephrotoxic and ototoxic potential, and intravenous vancomycin with an aminoglycoside raises acute kidney injury risk. Oral neomycin is minimally absorbed, but absorption can increase with impaired renal function or damaged gut mucosa.
How serious is the interaction between Neomycin and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough or AUC-based levels during combined therapy. Check hearing if therapy is prolonged or renal function declines.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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