Drug interactions
Neomycin + Voclosporin
Severity: Moderate
Neomycin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause dose-related nephrotoxicity. Neomycin may add to renal injury if absorbed systemically, as with renal impairment or damaged bowel.
What this interaction means in plain words
Neomycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity; voclosporin causes afferent arteriolar vasoconstriction and aminoglycosides cause tubular injury.
What to do
Monitor eGFR and creatinine closely and adjust voclosporin per labeling if renal function declines. Limit neomycin duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Neomycin with Voclosporin?
MediHelp rates the interaction as moderate. Neomycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause dose-related nephrotoxicity. Neomycin may add to renal injury if absorbed systemically, as with renal impairment or damaged bowel.
How serious is the interaction between Neomycin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and creatinine closely and adjust voclosporin per labeling if renal function declines. Limit neomycin duration.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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