Drug interactions
Neomycin + Warfarin
Severity: Moderate
Neomycin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin can enhance the anticoagulant effect of warfarin and raise the INR. This increases the risk of bleeding, particularly during prolonged courses.
What this interaction means in plain words
Neomycin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Reduction of vitamin K-producing intestinal flora and possibly impaired vitamin K absorption increases sensitivity to warfarin.
What to do
Monitor INR closely when starting or stopping oral neomycin and adjust the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Neomycin with Warfarin?
MediHelp rates the interaction as moderate. Neomycin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin can enhance the anticoagulant effect of warfarin and raise the INR. This increases the risk of bleeding, particularly during prolonged courses.
How serious is the interaction between Neomycin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when starting or stopping oral neomycin and adjust the warfarin dose as needed.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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