Drug interactions
Neomycin po + Penicillin g
Severity: Minor
Neomycin po and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin has been reported to reduce absorption of some oral penicillins, but oral penicillin G is already poorly and variably absorbed and is rarely used. For parenteral penicillin G there is no meaningful interaction.
What this interaction means in plain words
Neomycin po and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Neomycin may impair gastrointestinal absorption of oral penicillin through effects on the intestinal mucosa.
What to do
If oral penicillin therapy is needed, prefer an agent with reliable absorption such as penicillin V and monitor clinical response; no action for parenteral penicillin G.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Frequently asked questions
Can I take Neomycin po with Penicillin g?
MediHelp rates the interaction as minor. Neomycin po and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin has been reported to reduce absorption of some oral penicillins, but oral penicillin G is already poorly and variably absorbed and is rarely used. For parenteral penicillin G there is no meaningful interaction.
How serious is the interaction between Neomycin po and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If oral penicillin therapy is needed, prefer an agent with reliable absorption such as penicillin V and monitor clinical response; no action for parenteral penicillin G.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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