Drug interactions
Neostigmine + Solifenacin
Severity: Moderate
Neostigmine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neostigmine increases acetylcholine at muscarinic receptors while solifenacin blocks them, so the effects oppose each other. Solifenacin may reduce the peripheral muscarinic effects of neostigmine on bladder or gut, and could mask cholinergic adverse effects.
What this interaction means in plain words
Neostigmine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neostigmine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and an antimuscarinic.
What to do
Avoid concurrent use when the aim is to stimulate bladder or gut motility. When both are needed, monitor for loss of efficacy of either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Neostigmine
Frequently asked questions
Can I take Neostigmine with Solifenacin?
MediHelp rates the interaction as moderate. Neostigmine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neostigmine increases acetylcholine at muscarinic receptors while solifenacin blocks them, so the effects oppose each other. Solifenacin may reduce the peripheral muscarinic effects of neostigmine on bladder or gut, and could mask cholinergic adverse effects.
How serious is the interaction between Neostigmine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when the aim is to stimulate bladder or gut motility. When both are needed, monitor for loss of efficacy of either drug.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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