Drug interactions
Neratinib + Nicardipine
Severity: Moderate
Neratinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib is metabolized mainly by CYP3A4, and nicardipine may modestly increase its exposure, worsening diarrhea and hepatotoxicity. The effect is expected to be smaller than with strong inhibitors.
What this interaction means in plain words
Neratinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neratinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing neratinib clearance.
What to do
Monitor for diarrhea and liver enzyme elevation, using antidiarrheal prophylaxis per labeling. Consider an alternative antihypertensive if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Neratinib with Nicardipine?
MediHelp rates the interaction as moderate. Neratinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib is metabolized mainly by CYP3A4, and nicardipine may modestly increase its exposure, worsening diarrhea and hepatotoxicity. The effect is expected to be smaller than with strong inhibitors.
How serious is the interaction between Neratinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and liver enzyme elevation, using antidiarrheal prophylaxis per labeling. Consider an alternative antihypertensive if toxicity develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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