Drug interactions
Neratinib + Nizatidine
Severity: Moderate
Neratinib and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib absorption falls markedly when gastric pH rises, which may reduce its efficacy in breast cancer treatment.
What this interaction means in plain words
Neratinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neratinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Nizatidine raises gastric pH, reducing the pH-dependent solubility and absorption of neratinib.
What to do
Give neratinib at least 2 hours before the H2 blocker or 10 hours after it; avoid proton pump inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Neratinib with Nizatidine?
MediHelp rates the interaction as moderate. Neratinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib absorption falls markedly when gastric pH rises, which may reduce its efficacy in breast cancer treatment.
How serious is the interaction between Neratinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give neratinib at least 2 hours before the H2 blocker or 10 hours after it; avoid proton pump inhibitors.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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