Drug interactions
Netupitant-palonosetron + Rimegepant
Severity: Moderate
Netupitant-palonosetron and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. Higher rimegepant levels may increase the likelihood of adverse effects such as nausea and hypersensitivity reactions.
What this interaction means in plain words
Netupitant-palonosetron and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Rimegepant belongs to Central Nervous System.
Why it happens
Netupitant inhibits CYP3A4, reducing the metabolism of rimegepant, which is a CYP3A4 substrate.
What to do
Do not repeat the rimegepant dose within 48 hours when it is taken with netupitant. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Netupitant-palonosetron with Rimegepant?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. Higher rimegepant levels may increase the likelihood of adverse effects such as nausea and hypersensitivity reactions.
How serious is the interaction between Netupitant-palonosetron and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not repeat the rimegepant dose within 48 hours when it is taken with netupitant. Monitor for adverse effects.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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