Drug interactions
Netupitant-palonosetron + Sonidegib
Severity: Major
Netupitant-palonosetron and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may increase sonidegib exposure, raising the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
What this interaction means in plain words
Netupitant-palonosetron and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Sonidegib belongs to Oncology.
Why it happens
Netupitant inhibits CYP3A4, the main enzyme metabolizing sonidegib.
What to do
Avoid the combination where possible. If needed, limit the inhibitor to under 14 days and monitor for muscle symptoms and creatine kinase.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Netupitant-palonosetron with Sonidegib?
MediHelp rates the interaction as major. Netupitant-palonosetron and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Netupitant may increase sonidegib exposure, raising the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
How serious is the interaction between Netupitant-palonosetron and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, limit the inhibitor to under 14 days and monitor for muscle symptoms and creatine kinase.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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