Drug interactions
Netupitant-palonosetron + Tecovirimat
Severity: Minor
Netupitant-palonosetron and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower netupitant concentrations. This could in theory reduce antiemetic effectiveness, though the effect is likely small.
What this interaction means in plain words
Netupitant-palonosetron and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly induces CYP3A4, increasing netupitant metabolism.
What to do
No dose adjustment is needed. Monitor for breakthrough nausea and vomiting and treat with rescue antiemetics if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Netupitant-palonosetron with Tecovirimat?
MediHelp rates the interaction as minor. Netupitant-palonosetron and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower netupitant concentrations. This could in theory reduce antiemetic effectiveness, though the effect is likely small.
How serious is the interaction between Netupitant-palonosetron and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for breakthrough nausea and vomiting and treat with rescue antiemetics if needed.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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