Drug interactions
Nevirapine + Nitrendipine
Severity: Moderate
Nevirapine and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce nitrendipine exposure, leading to weaker blood pressure control. This is expected because nitrendipine undergoes extensive CYP3A4 first-pass metabolism.
What this interaction means in plain words
Nevirapine and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolism of nitrendipine.
What to do
Monitor blood pressure when nevirapine is started or stopped and increase the nitrendipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nevirapine and Nitrendipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Nitrendipine?
MediHelp rates the interaction as moderate. Nevirapine and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce nitrendipine exposure, leading to weaker blood pressure control. This is expected because nitrendipine undergoes extensive CYP3A4 first-pass metabolism.
How serious is the interaction between Nevirapine and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when nevirapine is started or stopped and increase the nitrendipine dose if needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
