Drug interactions
Nevirapine + Paclitaxel protein bound
Severity: Moderate
Nevirapine and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower paclitaxel exposure and potentially reduce antitumor efficacy. Paclitaxel is cleared by CYP2C8 and CYP3A4, and nevirapine induces both pathways to some extent.
What this interaction means in plain words
Nevirapine and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4 (and possibly CYP2C8), increasing paclitaxel metabolism.
What to do
Monitor tumor response and toxicity; there is no established dose adjustment, so consider an alternative antiretroviral if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Nevirapine and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower paclitaxel exposure and potentially reduce antitumor efficacy. Paclitaxel is cleared by CYP2C8 and CYP3A4, and nevirapine induces both pathways to some extent.
How serious is the interaction between Nevirapine and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity; there is no established dose adjustment, so consider an alternative antiretroviral if efficacy is a concern.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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