Drug interactions
Nevirapine + Parecoxib
Severity: Minor
Nevirapine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine could reduce conversion or clearance of parecoxib's active metabolite valdecoxib, potentially lowering analgesic effect. Valdecoxib is metabolized by CYP3A4 and CYP2C9, and the clinical effect is probably small.
What this interaction means in plain words
Nevirapine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nevirapine induces CYP3A4, increasing the metabolism of valdecoxib, the active metabolite of parecoxib.
What to do
Monitor analgesic response; no preemptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Parecoxib?
MediHelp rates the interaction as minor. Nevirapine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine could reduce conversion or clearance of parecoxib's active metabolite valdecoxib, potentially lowering analgesic effect. Valdecoxib is metabolized by CYP3A4 and CYP2C9, and the clinical effect is probably small.
How serious is the interaction between Nevirapine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response; no preemptive dose change is needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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