Drug interactions
Nevirapine + Pimozide
Severity: Moderate
Nevirapine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce pimozide concentrations through CYP3A4 induction, though the effect is variable. Pimozide has a narrow therapeutic index with QT prolongation risk, so fluctuations in exposure, including rebound if nevirapine is stopped, are important.
What this interaction means in plain words
Nevirapine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Pimozide belongs to Central Nervous System.
Why it happens
CYP3A4 induction by nevirapine increases pimozide clearance.
What to do
Monitor clinical response and ECG (QTc) when starting or stopping nevirapine, and adjust pimozide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Nevirapine with Pimozide?
MediHelp rates the interaction as moderate. Nevirapine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce pimozide concentrations through CYP3A4 induction, though the effect is variable. Pimozide has a narrow therapeutic index with QT prolongation risk, so fluctuations in exposure, including rebound if nevirapine is stopped, are important.
How serious is the interaction between Nevirapine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and ECG (QTc) when starting or stopping nevirapine, and adjust pimozide dose accordingly.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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