Drug interactions
Nevirapine + Teniposide
Severity: Moderate
Nevirapine and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may increase teniposide clearance and reduce exposure to the cytotoxic agent. This could compromise antineoplastic efficacy.
What this interaction means in plain words
Nevirapine and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, which metabolizes teniposide.
What to do
Monitor for reduced chemotherapy response. Consider a non-inducing antiretroviral regimen when chemotherapy is given with curative intent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Teniposide?
MediHelp rates the interaction as moderate. Nevirapine and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may increase teniposide clearance and reduce exposure to the cytotoxic agent. This could compromise antineoplastic efficacy.
How serious is the interaction between Nevirapine and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced chemotherapy response. Consider a non-inducing antiretroviral regimen when chemotherapy is given with curative intent.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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